Voice disorders affect one in ten children and adults at some point over their lifetime. Our lab focuses on the development of a computational platform that can guide surgeons and speech pathologists in the best methods to repair voices that have been lost.
In addition, we work in collaboration with engineers and surgeons to develop non-invasive assessment of vocal fold pathology and create biomaterial for vocal fold reconstruction.
This project is to develop patient-specific computational models that will predict treatment responses of patients with vocal diseases. The models will help clinicians tailor their care for individual patients with enhanced voice outcomes. Agent-based modeling with parallel computing and 3D visualization are exploited.
Collaborators: Prof. Joseph Jaja (University of Maryland) and Prof. Luc Mongeau (McGill University)
Macrophages and fibroblasts are central in wound healing from the control of infection and inflammation to repair of injury. This project is to investigate on vocal fold cell activities as a function of phonatory stress and extracellular matrix property using an in vitro bioreactor. The information will be useful in the design of biomaterial for vocal fold reconstruction.
Collaborators: Prof. Adam Hsieh (University of Maryland) and Prof. Luc Mongeau (McGill University)
The diagnosis of laryngeal disease is confirmed by conventional histopathology or tissue biopsy before treatment can begin. This approach entails physical removal of a small tissue specimen from patients, which can cause irreversible vocal fold scarring. We endeavor to develop fine needle aspiration tools for gene profiling and clinical multiphoton endoscope for in vivo visualizing vocal fold histology, minimizing the need of tissue biopsy.
Collaborators: Dr. Karen Kost (Montreal General Hospital), Prof. Susan Thibeault (University of Wisconsin-Madison), Prof. Luc Mongeau (McGill University) and Prof. Paul Wiseman (McGill University)
We are looking for smart, hard-working, and fun individuals to join our voice team. We currently have positions at doctoral and post-doctoral levels. We are looking for individuals with strong background in biomedical engineering, systems biology and/ or are proficient in computer programming with C++. For interested individuals, please send the CV, unofficial transcripts and a short description of why you're interested in our work to Dr. Nicole Li-Jessen.