Larynx is critical to our daily breathing, communication and swallowing functions. The VUA research lab focuses on advancing personalized medicine in voice and upper airway dysfunctions through the development of biological computing, point-of-care diagnostics, regenerative biomaterials and Internet of Medical Things (IoMT).
TThis project is to develop patient-specific computational models that will predict treatment responses of patients with vocal diseases. The models will help clinicians tailor their care for individual patients with enhanced clinical outcomes. Multiscale and hybrid modeling with parallel computing and 3D visualization are exploited.
Collaborators: Prof. Joseph Jaja (University of Maryland) and Prof. Luc Mongeau (McGill University)
Macrophages and fibroblasts are central in wound healing from the control of
infection and inflammation to repair of injury. This project is to investigate on vocal fold
cell activities as a function of phonatory stress and extracellular matrix property using an
in vitro bioreactor. The information will be useful in the design of biomaterial
for vocal fold reconstruction.
Collaborators: Prof. Luc Mongeau (McGill University)
The diagnosis of laryngeal disease is confirmed by conventional histopathology or tissue biopsy before treatment can begin. This approach entails physical removal of a small tissue specimen from patients, which can cause irreversible vocal fold scarring. We endeavor to develop clinical multiphoton endoscope for in vivo visualizing vocal fold histology, minimizing the need of tissue biopsy. We also invent a rapid protein assay platform for laryngopharyngeal reflux detection and monitoring, without going through time-consuming laboratory tests.
Collaborators: Dr. Karen Kost (Montreal General Hospital), Prof. Susan Thibeault (University of Wisconsin-Madison), Prof. Luc Mongeau (McGill University) and Prof. Paul Wiseman (McGill University)
If you share the same vision and research interests as of the VUA lab, we welcome you to join our dynamic and multi-disciplinary team. We currently have open positions (Ph.D. and post-doc) in our computational modeling/ simulation projects. Please send your CV, unofficial transcripts and a short description of why you're interested in our work to Dr. Nicole Li-Jessen.